Fasting mimicking diet (ProLon) by Valter Longo, PhD



Interventions that promote longevity, remembered by mnemonic: DEEP purple - “eat colorful plant foods: Dietary modification, Exercise, active Engagement, Purposeful living (click here to enlarge the image).

Valter D. Longo (born October 9, 1967) is an Italian-American biogerontologist and cell biologist known for his studies on the role of fasting and nutrient response genes on cellular protection aging and diseases and for proposing that longevity is regulated by similar genes and mechanisms in many eukaryotes. He is currently a professor at the USC Davis School of Gerontology with a joint appointment in the department of Biological Sciences as well as serving as the director of the USC Longevity Institute. Dr Longo (PhD) is widely publsihed, he has more than 120 articles listed in PubMed as of 2019: https://www.ncbi.nlm.nih.gov/pubmed/?term=Longo%20VD%5BAuthor%5D&cauthor=true&cauthor_uid=31442398

Valter Longo's longevity diet proposals relies on 2 major approaches:

1. Daily longevity diet, which is mostly plant-based with fish once to twice a week.

2. Episodic fasting mimicking diet, which is a 5-day low calorie diet. Fasting mimicking diet is used every 6 months to every 1 month based on the condition of the patient.

More details are available in the videos below and in Valter Longo's 2018 book, linked below.

Fasting mimicking diet (ProLon)

Valter Longo's fasting-mimicking diet (FMD) is a low-calorie, low-protein, low-carbohydrate, high-fat meal program that is claimed to mimic the effects of periodic fasting or water fasting over the course of five days, while still aiming to provide the body with nutrition. FMD is considered a periodic fast.[9]

Longo developed the diet at the University of Southern California. He believes that it is possible to mimic the effects of fasting with a meal program that is designed to inhibit the same metabolic pathways fasting would, thereby providing the body with nutrients that do not trigger the body’s growth responses (including stem cells).

Fasting mimicking diet is trademarked by L-Nutra, a company partially owned by Longo with financial interest by USC, though Longo does not receive any financial benefits from the company.

FMD application has been explored in patients with metabolic abnormalities, autoimmune disorders and cancers.

Here is a recent overview of the experience: https://www.technologyreview.com/s/614082/prolon-starvation-diet/

Mark Hyman, MD: The Secret Power of Fasting for Longevity and Healing, 2019:



References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528490/
https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.118.313352?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
https://www.amazon.com/Longevity-Diet-Discover-Activation-Regeneration/dp/0525534075
https://prolonpro.com/
https://www.youtube.com/watch?v=zz4ZzNik1Y4
https://www.technologyreview.com/s/614082/prolon-starvation-diet/
https://www.youtube.com/watch?v=dVArDzYynYc
https://www.bluezones.com/2016/04/fasting-for-longevity/
https://en.wikipedia.org/wiki/Valter_Longo
https://gero.usc.edu/faculty/longo/
https://www.youtube.com/watch?v=evGFWRXEzz8
https://www.kevinrose.com/post/valter-longo
https://www.statnews.com/2017/06/13/fasting-diet-valter-longo/
https://drhyman.com/blog/2019/04/10/podcast-ep48/
http://casesblog.blogspot.com/2018/12/exceptional-longevity-why-some-people.html
https://valterlongo.com/recipes-of-longevity/

Michal Kosinski: "The End of Privacy" | Talks at Google

Michal Kosinski is an Assistant Professor of Organizational Behavior at Stanford’s Graduate School of Business. He has published on privacy risks, psychometrics, and psychological profiling.

"Cardio IQ Advanced Cardiovascular Tests" by Quest

"Cardio IQ Advanced Cardiovascular Tests" are marketed by Quest labs and recently discussed by Dr Hyman and Dr Attea here: https://www.youtube.com/watch?v=n5bLggnbtyI

Quest has a 2016 webinar that discussed why Advanced Cardiovascular testing is beneficial, reviewed two cardiovascular risk factors Lp(A) and ApoB, biomarkers for assessment of inflammation, clinical importance of LDL sub-fractions, introduced the Cardio IQ Report as a management solution beyond the routine lipid panel: https://education.questdiagnostics.com/presentations/advanced-insights-into-residual-cardiovascular-risk?presentation_id=262

More info about the test and examples are here: https://www.questdiagnostics.com/home/physicians/testing-services/condition/cardiovascular/cardio-iq-report.html

Here are additional tests focused on cardiovascular and metabolic diseases:
https://www.questdiagnostics.com/home/physicians/testing-services/condition/cardiovascular/cvd-test-descriptions.html

References:
https://www.questdiagnostics.com/home/physicians/testing-services/condition/cardiovascular/cardio-iq-report.html
https://www.questdiagnostics.com/home/physicians/testing-services/condition/cardiovascular/cvd-test-descriptions.html
https://www.questdiagnostics.com/dms/Documents/cardio/PT04-AdvancedCardiovascularTests.pdf
https://education.questdiagnostics.com/presentations/advanced-insights-into-residual-cardiovascular-risk?presentation_id=262

Making the impossible look effortless... for hundreds of years

Ian Gillan, singer/songwriter of the hard rock legendary band Deep Purple, on the musicianship of his colleagues at 1:30 min in the video below: "performing live, they are making the impossible look effortless."

That's a good goal for any profession. And you just hope you can continue doing for "hundreds of years."



Source:

https://www.thehighwaystar.com/news/2019/05/28/well-be-back-in-300-years/

Cleveland Clinic in London

The new Cleveland Clinic building in London is growing from within - see for yourself - it's just across from the Buckingham Palace:



Cleveland Clinic London is on track to open a new 200-bed private healthcare facility near Buckingham Palace in January 2021. The opening will coincide with the system's centennial.

https://clevelandcliniclondon.uk



Cleveland Clinic London will focus on 4 specialties: cardiology, orthopedics, digestive disease and neurology. And it will open 3 outpatient facilities. The Clinic will employ about 50 doctors and a staff of about 200.

https://www.cleveland.com/healthfit/2018/08/cleveland_clinic_london_openin_1.html

Disclaimer: I work as an Allergist/Immunologist at Cleveland Clinic Florida.