How Balding Became Big Business, and the market is expected to grow even further - WSJ video

How Balding Became Big Business - WSJ video: Only 2 medications are FDA-approved as of 2019: minoxidil and finasteride:



References:

https://on.wsj.com/32SeoPz

How to Take Care of Your Eyes as You Age: be aware of GMC: Glaucoma, Macular degeneration, Cataract

From Consumer Reports:

Glaucoma

More than 2 million Americans have glaucoma, but 50% know it. Glaucoma often goes undiagnosed because it causes no symptoms until vision declines, at which point treatment no longer helps. People aged 40-60 should be examined by an optometrist every 3-5 years; those older than 60 need an eye exam every 1-2 years.

Many eye doctors screen for glaucoma with tonometry (measures eye pressure) but that’s not enough. Relying only on intraocular pressure (IOP) when screening for glaucoma could miss up to 50% of all cases. The exam should also include an ophthalmoscopy, which involves examining your optic nerve.

The most common treatment for glaucoma is eye drops known as prostaglandin analogs (PGAs), which lower eye pressure. Generic versions of most of those drugs are much cheaper than the brand-name versions.

Age-related Macular Degeneration (AMD)

There are two main forms of AMD:

1. Dry AMD, more common variety, which is treated mainly with dietary supplements

A specific blend of vitamins and minerals known as AREDS (vitamins C and E, plus copper, lutein, zeaxanthin, and zinc) lowers the risk of dry AMD progression by 25%. It’s the only treatment as of 2019.

Not all eye supplements contain the proper formulation. In an analysis of 11 eye-health supplements, only 4 contained the right mix: PreserVision Eye Vitamin AREDS Formula, PreserVision Eye Vitamin Lutein Formula, PreserVision AREDS2 Formula, and ICAPS AREDS.

Don’t bother taking any supplement with the hope that it will prevent AMD, no research supports that as of 2019.

2. Wet AMD, the more serious form, which requires monthly injections from an ophthalmologist with one of three drugs.

For wet AMD, consider an inexpensive drug vs the expensive ones. There are 3 drugs used to treat wet AMD—aflibercept (Eylea), bevacizumab (Avastin), and ranibizumab (Lucentis). Avastin costs just $50 per month, compared with $2,000 for the others. Avastin is officially approved only as a cancer drug and and you would need a compounding pharmacy.

References:

https://www.consumerreports.org/vision-eye-care/how-to-take-care-of-your-eyes-as-you-age/

Keep Things Simple For A Healthy, and Hopefully Longer, Life

By my former colleague at the University of Chicago, John Schumann: Keep Things Simple For A Healthy, Long Life:

1. Get enough sleep.

2. Move your body throughout the day.

3. Eat well — a healthy assortment of foods. Mostly plants, and not too much.

4. Interact socially. Isolation is not good for the body, soul or mind.

5. Take some time to reflect on what you are grateful for.



Interventions that promote longevity, remembered by mnemonic: DEEP purple - “eat colorful plant foods: Dietary modification, Exercise, active Engagement, Purposeful living (click here to enlarge the image).

References:

https://www.npr.org/sections/health-shots/2016/01/02/459970110/keep-things-simple-for-a-healthy-long-life

Being hungry may lead to poor decisions, focused on on short-term rewards

There is evidence that hunger increases discounting for food rewards, biasing choices towards smaller but sooner food reward over larger but later reward.

Researchers found strong evidence that hunger causes large increases in delay discounting for food, with an approximately 25% spillover effect to non-food commodities. This discounting can cause negative outcomes in many non-food domains:

- consumer
- investment
- medical
- inter-personal

Caution may be necessary when making decisions involving non-food outcomes while hungry.

In conclusion, sleep and eat on it, before making a final decision.

References:

https://link.springer.com/article/10.3758/s13423-019-01655-0

https://www.irishexaminer.com/breakingnews/world/empty-stomachs-lead-to-poor-decisions-research-says-951019.html

Fasting mimicking diet (ProLon) by Valter Longo, PhD



Interventions that promote longevity, remembered by mnemonic: DEEP purple - “eat colorful plant foods: Dietary modification, Exercise, active Engagement, Purposeful living (click here to enlarge the image).

Valter D. Longo (born October 9, 1967) is an Italian-American biogerontologist and cell biologist known for his studies on the role of fasting and nutrient response genes on cellular protection aging and diseases and for proposing that longevity is regulated by similar genes and mechanisms in many eukaryotes. He is currently a professor at the USC Davis School of Gerontology with a joint appointment in the department of Biological Sciences as well as serving as the director of the USC Longevity Institute. Dr Longo (PhD) is widely publsihed, he has more than 120 articles listed in PubMed as of 2019: https://www.ncbi.nlm.nih.gov/pubmed/?term=Longo%20VD%5BAuthor%5D&cauthor=true&cauthor_uid=31442398

Valter Longo's longevity diet proposals relies on 2 major approaches:

1. Daily longevity diet, which is mostly plant-based with fish once to twice a week.

2. Episodic fasting mimicking diet, which is a 5-day low calorie diet. Fasting mimicking diet is used every 6 months to every 1 month based on the condition of the patient.

More details are available in the videos below and in Valter Longo's 2018 book, linked below.

Fasting mimicking diet (ProLon)

Valter Longo's fasting-mimicking diet (FMD) is a low-calorie, low-protein, low-carbohydrate, high-fat meal program that is claimed to mimic the effects of periodic fasting or water fasting over the course of five days, while still aiming to provide the body with nutrition. FMD is considered a periodic fast.[9]

Longo developed the diet at the University of Southern California. He believes that it is possible to mimic the effects of fasting with a meal program that is designed to inhibit the same metabolic pathways fasting would, thereby providing the body with nutrients that do not trigger the body’s growth responses (including stem cells).

Fasting mimicking diet is trademarked by L-Nutra, a company partially owned by Longo with financial interest by USC, though Longo does not receive any financial benefits from the company.

FMD application has been explored in patients with metabolic abnormalities, autoimmune disorders and cancers.

Here is a recent overview of the experience: https://www.technologyreview.com/s/614082/prolon-starvation-diet/

Mark Hyman, MD: The Secret Power of Fasting for Longevity and Healing, 2019:



References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528490/
https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.118.313352?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
https://www.amazon.com/Longevity-Diet-Discover-Activation-Regeneration/dp/0525534075
https://prolonpro.com/
https://www.youtube.com/watch?v=zz4ZzNik1Y4
https://www.technologyreview.com/s/614082/prolon-starvation-diet/
https://www.youtube.com/watch?v=dVArDzYynYc
https://www.bluezones.com/2016/04/fasting-for-longevity/
https://en.wikipedia.org/wiki/Valter_Longo
https://gero.usc.edu/faculty/longo/
https://www.youtube.com/watch?v=evGFWRXEzz8
https://www.kevinrose.com/post/valter-longo
https://www.statnews.com/2017/06/13/fasting-diet-valter-longo/
https://drhyman.com/blog/2019/04/10/podcast-ep48/
http://casesblog.blogspot.com/2018/12/exceptional-longevity-why-some-people.html
https://valterlongo.com/recipes-of-longevity/