Oral Rivaroxaban signals the beginning of the end of Lovenox use for DVT prophylaxis

Rivaroxaban is an oral anticoagulant under development by Bayer; it will be marketed as Xarelto. It acts by inhibiting the active form of coagulation factor X (factor Xa).


Fig 1. The coagulation cascade. Legend: Black arrow = conversion/activation of factor. Red arrows = action of inhibitors. Blue arrows = reactions catalysed by activated factor. Grey arrow = various functions of thrombin. Image source: Wikipedia

According to 2 NEJM studies, a once-daily, 10-mg oral dose of rivaroxaban was significantly more effective for extended thromboprophylaxis than a once-daily, 40-mg subcutaneous dose of enoxaparin (Lovenox) in patients undergoing elective total and knee and hip arthroplasty. The two drugs had similar safety profiles.

Due to the decreased need for monitoring, rivaroxaban is likely to be used to replace warfarin for a number of indications, such as atrial fibrillation.

A related drug, ximelagatran, a direct thrombin inhibitor, was not marketed further due to its potential side-effects, mainly liver toxicity.

Oral rivaroxaban is non-inferior to standard therapy for symptomatic pulmonary embolism (PE) and DVT (NEJM, 2012).

References:

Rivaroxaban versus Enoxaparin for Thromboprophylaxis after Total Knee Arthroplasty. NEJM, 06/2008.
Rivaroxaban versus Enoxaparin for Thromboprophylaxis after Hip Arthroplasty. NEJM, 06/2008.

Related:

An oral anticoagulant in the pipeline. Notes from Dr. RW: Was Lovenox dose intentionally too low (40 mg sq qd instead of 30 mg sq bid)?

1 comment:

  1. This is a very interesting drug. I wish it would be tested as well in patients with hip fracture, not just elective arthroplasty - as in hip fracture the best thromboprophylaxis is fondaparinux.

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