- Researchers make synthetic HDL cholesterol
- Synthetic HDL has a tiny core of gold -- "the idea is you take this and just urinate it out"
Lipoprotein structure (chylomicron) (left). Image source: Wikipedia, GNU Free Documentation License. Three pieces of native gold (right). Image source: Wikipedia, public domain.
- Merck develops an HDL-raising drug called anacetrapib, plans to start late-stage trials in humans in 2009
- Merck's compound has similar mechanism of action to a failed drug by Pfizer called torcetrapib, linked to deaths
- CETP Inhibitor Evacetrapib Increases HDL, according to 2011 study published in JAMA
Anacetrapib. Image source: Wikipedia, public domain.
- Both anacetrapib and torcetrapib are CETP inhibitors. CETP is an abbreviation for cholesterylester transfer protein - a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins
Researchers make synthetic HDL cholesterol: study. Reuters.
Effects of the CETP Inhibitor Evacetrapib Administered as Monotherapy or in Combination With Statins on HDL and LDL Cholesterol, November 16, 2011, Nicholls et al. 306 (19): 2099. JAMA.
Monounsaturated fats found in vegetable oils, nuts and avocados increase "good" HDL cholesterol levels by 12% http://goo.gl/GBQa5