The authors of this NEJM study hypothesized that emphysema, as detected on computed tomography (CT), and airflow obstruction are inversely related to left ventricular end-diastolic volume, stroke volume, and cardiac output among persons without very severe lung disease.
Of the study participants, 13% were current smokers, 38% were former smokers, and 49% had never smoked.
A 10% increase in emphysema on CT was related to decrease in left ventricular end-diastolic volume, stroke volume, and cardiac output.
Percent emphysema and airflow obstruction were not associated with the left ventricular ejection fraction (LVEF).
Percent Emphysema, Airflow Obstruction, and Impaired Left Ventricular Filling. R. Graham Barr et al. NEJM Volume 362:217-227 January 21, 2010 Number 3.
Image source: Enlarged view of lung tissue showing the difference between healthy lung and COPD, Wikipedia, public domain.