Lipoprotein-associated phospholipase A2 increases risk of coronary disease

Lipoprotein-associated phospholipase A2 (Lp-PLA2), an inflammatory enzyme expressed in atherosclerotic plaques, is a therapeutic target being assessed in trials of vascular disease prevention.

Lp-PLA2 activity and mass each show continuous associations with risk of coronary heart disease, similar in magnitude to that with non-HDL cholesterol or systolic blood pressure.

Lipoprotein structure (chylomicron). Image source: Wikipedia, GNU Free Documentation License.


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