Lifespan vs. healthspan: "I'LL do it" mnemonic


"Tthere is nobody who disputes that epigenetics predicts life span”. Aging eight or more years faster than your calendar age equates to twice the typical risk of dying, while aging seven years slower is associated with half the risk of death, Horvath says.

"Life span predictor" clock

His lab has developed a "life span predictor" they named it after the Grim Reaper: DNAm GrimAge. The epigenetic clock is more accurate the younger a person is. It’s especially inaccurate for the very old. “At this point, we don’t have any evidence that it’s clinically useful, because there are big error bars.”

Seed of the clock is strongly influenced by underlying genes: 40% of the ticking rate is determined by genetic inheritance, and the rest by lifestyle and luck: "I'LL do it" mnemonic:


Eating a healthy diet including lots of vegetables and fish is associated with slower epigenetic aging. Sleep deprication speeds the clock. The big suprise: Regular exercise won’t add much more than a few months to your life! You probably spend way more time exercising that the time you are going to get at the end of your lifespan.

Nobody really knows about timing of the final day

From his opponents: Diane Meier, a professor of geriatrics and palliative medicine at the Icahn School of Medicine at Mount Sinai in New York City: “I haven’t seen any of these purported predictive algorithms be precise in terms of timing of death—to the contrary,” says . “People live for a really long time with a very high burden of disease and frailty.”


Want to know when you’re going to die?

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