Where does your state rank in terms of life expectancy? Only Hawaii is over 80 years

People in some southern states can expect to die 8 years younger than the average American, according to a data compilation that highlights the disparities in US life expectancy.

While Americans lived for 79 years on average in 2020, those in Mississippi can expect to reach just 71.

For comparison, people in Hawaii — which has the highest life expectancy — live to 80 on average. 

The Daily Mail credits the summary to an online pharmacy, NiceRx, it's probably just a compilation of publicly available data. 



New option for H pylori treatment: Voquezna

 The Food and Drug Administration (FDA) has approved the following new medication for the treatment of Helicobacter pylori (H. pylori) infection in adults.:

- Voquezna Triple Pak (vonoprazan, amoxicillin, clarithromycin)
- Voquezna Dual Pak (vonoprazan, amoxicillin)

Vonoprazan, which gives the name of the medication, is an oral small molecule potassium-competitive acid blocker.

H. pylori eradication rates were 84.7% and 78.5% with Voquezna Triple and Dual Pak, respectively.

Voquezna Triple Pak is supplied as a carton containing 56-tablets and 56-capsules divided into 14 daily dose blister cards. Each daily blister card contains 2 vonoprazan tablets (20mg each), 4 amoxicillin capsules (500mg each), and 2 clarithromycin tablets (500mg each).

Voquezna Dual Pak is supplied as a carton containing 28-tablets and 84-capsules divided into 14 daily dose blister cards. Each daily blister card contains 2 vonoprazan tablets (20mg each) and 6 amoxicillin capsules (500mg each).


Physiological Effects of Ancient Religious Chants

Several studies have explore the effects of religious changes, such as OM, on physiological parameters such as heart rate, blood pressure and heat rate variability (HRV). 

Overall, the effects were considered beneficial.

For example, a brief chanting of OM (5 min) might enhance parasympathetic nervous system activity, promote relaxation, and provide calmness. 

Rhythm formulas that involve breathing at 6 breaths per minute induced favorable psychological and possibly physiological effects. Breathing at 6 breaths per minute is very close to so called resonance frequency breathing for most people.


Physiological Effects of Cryptic Ancient Religious Chants.  Abhijit. V. Bodne    Varsha Patond. Journal of Pharmaceutical Research International, Volume 33, Issue 60B, Page 1042-1048 DOI: 10.9734/jpri/2021/v33i60B34711 Published: 23 December 2021

Effect of rosary prayer and yoga mantras on autonomic cardiovascular rhythms: comparative study. BMJ. 2001 Dec 22; 323(7327): 1446–1449. doi: 10.1136/bmj.323.7327.1446  PMCID: PMC61046 PMID: 11751348

Immediate Effects of OM Chanting on Heart Rate Variability Measures Compared Between Experienced and Inexperienced Yoga Practitioners. Int J Yoga. 2022 Jan-Apr; 15(1): 52–58. Published online 2022 Mar 21. doi: 10.4103/ijoy.ijoy_141_21 PMCID: PMC9015091 PMID: 35444369

Understand risk better by using "micromort" unit

A micromort (from micro- and mortality) is a unit of risk defined as a one-in-a-million chance of death.

Micromorts can be used to measure the riskiness of various day-to-day activities.

Activities that increase the death risk by roughly one micromort, and their associated cause of death:

Traveling 250 miles by car (collision) Travelling 1,000 miles (1,600 km) by jet (collision) Travelling 6,000 miles (9,656 km) by train (collision)

 Increase in death risk for other activities on a per event basis:

Giving birth (vaginal) – 120 micromorts
Giving birth (caesarean) – 170 micromorts
AstraZeneca vaccination against COVID-19 – 2.9 micromorts
COVID-19 infection at age 10 – 20 micromorts
COVID-19 infection at age 25 – 100 micromorts
COVID-19 infection at age 55 – 4,000 micromorts
COVID-19 infection at age 65 – 14,000 micromorts
COVID-19 infection at age 75 – 46,000 micromorts
COVID-19 infection at age 85 – 150,000 micromorts

More info here: https://en.wikipedia.org/wiki/Micromort

Dopamine elevation after a cold bath

Dopamine elevation after cold bath is due to stimulation of pain receptors in the skin, at 2 minutes in the video below: https://www.youtube.com/watch?v=QmOF0crdyRU Norepi, Epi and dopamine were all increased with cold water exposure. Dopamine increased 250% over baseline and that increase was sustained after the exposure for up to 3 hours. The sweet spot is alert but calm. That was achieved via the cold exposure. Calm/alert state. Cold exposure can be equivalent to coffee without the jitters. Mnemonics: D Dopamine Drives Determination and motivation C Cold water exposure Calm/alert state At 42 minutes. Chocolate increases dopamine 150% for a few minutes. Sex increases dopamine 200%. Nicotine increases dopamine 250% for a few minutes. Same increase with cocaine. Amphetamine increases dopamine 10 times. Exercise, if you like it, increases dopamine 200%. If you don't like the exercise, dopamine does not go up. Postpartum depression can appear after every big win, not just labor. That lower mood can last a long time. It is due to lower baseline dopamine levels. At 55 minutes. Cold bath can counteract this because it may increase baseline dopamine level for at least a portion of the day. We all have dopamine set point. More on cold water exposure at 1 hr 30 minutes. Safety parameters: 30 to 40F degree water can put someone in the state of cold shock and they can die. Cold water exposure always causes release of epinephrine, even after you are cold-water adapted. Increase in epi and nor-epi is immediate. Dopamine levels increases slowly to the point of 250% over baseline. It takes 3 hours for dopamine to go back to baseline. How to deal with the cold in a peaceful manner: Relax in the cold, breathe slowly, widen your gaze - switch from portrait to landscape mode. At 1 hr 35 minutes. Velvet beans contain L-DOPA at 1 hr 58 minutes. Dopamine and prolactin work in push-pull fashion. Increase in dopamine is linked with lower prolactin.