Most Antidepressants Are Equally Effective. Side Effects Determine Choice

This meta-analysis reviewed trials comparing one second-generation antidepressant with another (Annals of Int Med). The conclusion was that antidepressants do not differ substantially in terms of efficacy.

No evidence to recommend a particular second-generation antidepressant on the basis of efficacy (Ann of Int Med, 2011, http://goo.gl/qG8P8).

References:

All Antidepressants Are Equally Effective. Side Effects Determine Choice - WebMD 9/05.
Efficacy and Safety of Second-Generation Antidepressants in the Treatment of Major Depressive Disorder - Ann of Int Med 9/05.