An oral inhibitor of hedgehog pathway has antitumor activity

Hedgehog signaling pathway is one of the key regulators of animal development conserved from flies to humans http://bit.ly/17cs4t

Sonic hedgehog homolog (SHH) is one of 3 proteins in the mammalian hedgehog family (plus desert and Indian hedgehog). Sonic hedgehog controls cell division of adult stem cells and has been implicated in development of some cancers http://bit.ly/ODlig

An oral inhibitor of hedgehog pathway has antitumor activity in locally advanced or metastatic basal-cell carcinoma http://bit.ly/3ufxWx

Image source: Sonic hedgehog specifies digit identity in mammalian development. Wikipedia, public domain.

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